Pan-cancer prevalence, risk, and clinical and demographic characteristics of Lynch Syndrome-associated variants in BioBank Japan
This study provides critical insights for clinical guidelines on the associations between cancer types, age at diagnosis, and carrier frequency.
Authors
- Yukihide Momozawa (ORCID: https://orcid.org/0000-0001-5638-3504)
- Chikashi C. Terao (ORCID: https://orcid.org/0000-0002-6452-4095)
- Satoshi Takahashi (ORCID: https://orcid.org/0009-0006-0733-6094)
- Yoshiaki Usui (ORCID: https://orcid.org/0000-0001-6180-0704)
- Kouya Shiraishi (ORCID: https://orcid.org/0000-0002-5821-7400)
- Takashi Kohno (ORCID: https://orcid.org/0000-0002-5371-706X)
- Yoichiro Kamatani (ORCID: https://orcid.org/0000-0001-8748-5597)
- Yoshiki Mochizuki (ORCID: https://orcid.org/0009-0009-6935-4230)
- Kokichi Sugano (ORCID: https://orcid.org/0000-0001-6729-366X)
- Yuriko N. Koyanagi (ORCID: https://orcid.org/0000-0002-5675-3429)
- Keijiro Mizukami (ORCID: https://orcid.org/0000-0001-6023-3242)
- Masayuki Yamaguchi (ORCID: https://orcid.org/0000-0002-8185-9882)
- Keitaro Matsuo (ORCID: https://orcid.org/0000-0003-1761-6314)
- Koichi Matsuda (ORCID: https://orcid.org/0000-0001-7292-2686)
- Yoshinori Murakami (ORCID: https://orcid.org/0000-0002-2826-4396)
- Hidewaki Nakagawa (ORCID: https://orcid.org/0000-0003-1807-772X)
- Makoto Hirata (ORCID: https://orcid.org/0000-0002-9994-9958)
- Yusuke Iwasaki
- Amanda B. Spurdle (ORCID: https://orcid.org/0000-0003-1337-7897)
- Teruhiko Yoshida
- Mikiko Endo
Institutions
- QIMR Berghofer Medical Research Institute (AU)
- Sasaki Institute (JP)
- Aichi Cancer Center (JP)
- National Cancer Center Hospital East (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Nagoya University (JP)
- The University of Tokyo (JP)
- Nippon Medical School (JP)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1038/s43856-025-01231-9
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Japan Agency for Medical Research and Development
- National Health and Medical Research Council
- RIKEN