Development of a novel ultrashort antimicrobial peptide-levofloxacin conjugate with enhanced synergistic activity against multidrug and levofloxacin-resistant bacterial isolates
The UP5-levofloxacin conjugate demonstrated enhanced antimicrobial efficacy against resistant bacteria, with minimal hemolytic activity and favorable selectivity toward normal cells. This conjugate presents a promising approach to combating antimicrobial resistance, offering potential for improved therapeutic strategies.
Authors
- Aseel Alrashdan
- Ammar Almaaytah (ORCID: https://orcid.org/0000-0002-7804-3313)
- Salsabeel H. Sabi (ORCID: https://orcid.org/0000-0003-4629-5652)
Institutions
- Jordan University of Science and Technology (JO)
- Hashemite University (JO)
- Gulf Medical University (AE)
Publication Details
- Journal
- Research in Pharmaceutical Sciences
- Published
- 2025-11-01
- DOI
- https://doi.org/10.4103/rps.rps_178_24
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00