Neuroprotective properties of erythropoietin (Epo) and its receptor (EpoR) in open spinal dysraphism (OSD): an investigation of EpoR expression in a rat OSD model, along with in vitro studies on the neuroprotective effects of Epo on rat spinal cord-d
Induction of EpoR in neuroplacodes, its co-staining with neuronal and NPC markers, and the neuroprotective effects of Epo on aAF-treated NPCs in vitro establish Epo as a promising candidate for neuroprotective therapies that can supplement surgical measures for OSD.
Authors
- Michael Synowitz (ORCID: https://orcid.org/0000-0003-0427-6832)
- Friederike Knerlich‐Lukoschus (ORCID: https://orcid.org/0000-0003-4907-015X)
- Dana Hellmold (ORCID: https://orcid.org/0000-0001-9891-4342)
- Janka Held‐Feindt (ORCID: https://orcid.org/0000-0002-1304-2694)
- Jacqueline Clüver
- Frieda Bayler
- Inez Manczuk
Institutions
- University Hospital Schleswig-Holstein (DE)
- Universitätsmedizin Göttingen (DE)
- University of Göttingen (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Child s Nervous System
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1007/s00381-025-07032-8
- Primary Topic
- Erythropoietin and Anemia Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00