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Gal-9 increased IL-1β level as a critical inflammatory cytokine in the proliferation and resistance of AML cells to therapy. According to this finding, targeting and blocking the TIM-3/Gal-9 autocrine loop can suppress IL-Ιβ production and facilitate AML treatment.
Authors
- Behnaz Yazdani (ORCID: https://orcid.org/0000-0002-4243-1330)
- Hajar Sirous (ORCID: https://orcid.org/0000-0003-4311-9952)
- Ameneh Heydarian
Institutions
- Isfahan University of Medical Sciences (IR)
- Universitat de Vic - Universitat Central de Catalunya (ES)
- Islamic Azad University Medical Branch of Tehran (IR)
- Islamic Azad University Pharmaceutical Sciences Branch (IR)
Publication Details
- Journal
- Research in Pharmaceutical Sciences
- Published
- 2025-11-01
- DOI
- https://doi.org/10.4103/rps.rps_52_24
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00