Soluble urokinase plasminogen activator receptor is a prognostic biomarker in decompensated cirrhosis
Our study identifies soluble urokinase plasminogen activator receptor (suPAR) as a biomarker of liver-derived systemic inflammation that is clinically relevant for predicting adverse outcomes in decompensated cirrhosis and is associated with disease progression, organ dysfunction, and mortality. Systemic suPAR levels ≥14.0 ng/ml independently predicted 90-day mortality in patients with decompensated cirrhosis across two independent cohorts. Accurate outcome prediction is crucial for developing tailored, personalized treatments in advanced chronic liver disease, and suPAR, as an independent predictor of short-term mortality and disease progression, may complement established scoring systems such as MELD.
Authors
- Sven Lamatsch
- Hilmar Berger (ORCID: https://orcid.org/0000-0002-6304-4946)
- Nirbaanjot Walia (ORCID: https://orcid.org/0000-0002-2186-7290)
- Janett Fischer (ORCID: https://orcid.org/0000-0002-8710-101X)
- Kai Kappert (ORCID: https://orcid.org/0000-0001-6976-0428)
- Mohsin Hassan (ORCID: https://orcid.org/0000-0002-3796-8846)
- Fausto Andreola (ORCID: https://orcid.org/0000-0003-4926-0121)
- Carlos de la Peña-Ramirez
- Rajiv Jalan (ORCID: https://orcid.org/0000-0002-7747-4015)
- Jonas Schumacher (ORCID: https://orcid.org/0000-0002-5671-3160)
- Richard Sittner
- Münevver Demir (ORCID: https://orcid.org/0000-0002-7050-797X)
- Qingquan Bai (ORCID: https://orcid.org/0000-0003-0612-9801)
- Florian van Bömmel (ORCID: https://orcid.org/0000-0003-2679-0672)
- Zhengyang Zhao (ORCID: https://orcid.org/0000-0002-2208-9582)
- Niklas Aehling (ORCID: https://orcid.org/0000-0002-2258-847X)
- Rhea Veelken
- Fabian Jost‐Brinkmann (ORCID: https://orcid.org/0000-0002-4018-9720)
- Thomas Berg (ORCID: https://orcid.org/0000-0003-0003-6241)
- Pavitra Kumar (ORCID: https://orcid.org/0000-0002-8233-2273)
- Frank Tacke (ORCID: https://orcid.org/0000-0001-6206-0226)
- Raphael Mohr (ORCID: https://orcid.org/0000-0003-2403-4275)
- Rajeshwar P. Mookerjee (ORCID: https://orcid.org/0000-0002-6275-9384)
- Juan Wang (ORCID: https://orcid.org/0000-0001-6027-1505)
- Tianhui Hu (ORCID: https://orcid.org/0000-0003-3998-5145)
- Cornelius Engelmann
Institutions
- Xiamen University (CN)
- The Royal Free Hospital (GB)
- University Hospital Augsburg (DE)
- Humboldt-Universität zu Berlin (DE)
- European Foundation for the Study of Chronic Liver Failure (ES)
- Vivantes Klinikum (DE)
- University Hospital Leipzig (DE)
- University College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
- Leipzig University (DE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101677
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00