Central nervous system involvement-positive disease in consolidation/maintenance stage is a poor prognostic factor in pediatric T-cell acute lymphoblastic leukemia: a Chinese single-center report
CNSI+ disease, especially in the consolidation/maintenance stage, was an independent poor prognostic factor in pediatric T-ALL. HSCT partially improved outcomes of children with T-ALL. Individualized treatment strategies containing a combination of immunotherapy and targeted therapy in addition to chemotherapy may improve patient outcomes.
Authors
- Xiaoming Liu (ORCID: https://orcid.org/0000-0003-4502-237X)
- Ye Guo (ORCID: https://orcid.org/0000-0002-1813-9815)
- L Zhang (ORCID: https://orcid.org/0000-0002-8403-0228)
- Yao Zou (ORCID: https://orcid.org/0009-0002-7247-4937)
- Xiaojuan Chen (ORCID: https://orcid.org/0000-0001-7330-0993)
- Xiaofan Zhu (ORCID: https://orcid.org/0000-0001-7987-7793)
- Yumei Chen (ORCID: https://orcid.org/0000-0002-0241-7577)
- Wenyu Yang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- The Oncologist
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1093/oncolo/oyaf383
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences
- Peking Union Medical College
- State Key Laboratory of Experimental Hematology