Tanshinone ⅡA Inhibits Alveolar Macrophage Polarization, Inflammation and Mitochondrial Damage by Regulating the PAPR-1 Signaling Pathway
These findings suggest that the therapeutic effects of tanshinone IIA on pulmonary inflammation are closely related to its ability to inhibit inflammatory damage and oxidative stress, regulate AM polarization, and alleviate mitochondrial damage in AMs through modulation of the PARP-1 pathway.
Authors
- Jiefei Liang (ORCID: https://orcid.org/0000-0001-7384-2792)
- Xiuhua Yang (ORCID: https://orcid.org/0000-0002-4949-131X)
- Na Zhang (ORCID: https://orcid.org/0000-0002-3493-8051)
- Weibin Wu
- Chao Luo (ORCID: https://orcid.org/0000-0002-6233-3287)
- Chunyan Zhu (ORCID: https://orcid.org/0000-0002-0138-0450)
- Guo-Hua Shen
Institutions
- Zhaoqing University (CN)
- Shaoxing University (CN)
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-11-15
- DOI
- https://doi.org/10.5812/ijpr-166272
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00