RNA interference mediated mortality in Aedes albopictus: a challenging journey toward species-specific vector control
All target genes were significantly silenced in cells, and IAP in larval gut tissue. Although TRs improved dsRNA stability in vitro, no significant larval mortality was observed, likely due to rapid gut degradation. Therefore, effective RNAi-based control of Ae. albopictus requires identifying gut-specific essential genes and improved delivery systems.
Authors
- Bodunrin Omokungbe (ORCID: https://orcid.org/0000-0002-7216-2194)
- Pamela A Geisler
- Magnus Wolf (ORCID: https://orcid.org/0000-0001-9212-9861)
- Antje Steinbrink
- Andreas Vilcinskas (ORCID: https://orcid.org/0000-0001-8276-4968)
- Sabrina Stiehler
- Kornelia Hardes (ORCID: https://orcid.org/0009-0000-1670-7383)
- Alejandra Centurión
Institutions
- Justus-Liebig-Universität Gießen (DE)
- Institute for Biodiversity (DE)
- Senckenberg Biodiversity and Climate Research Centre (DE)
- LOEWE Centre for Translational Biodiversity Genomics (DE)
- Fraunhofer Institute for Molecular Biology and Applied Ecology (DE)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13071-025-07113-2
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- International Atomic Energy Agency
- Technische Universität München
- Tartu Ülikool