Catalpol attenuates postmenopausal osteoporosis by activating SIRT1-mediated P53 deacetylation and inhibiting CASPASE-3-driven osteoblast apoptosis
These findings support a SIRT1-centered mechanism whereby CAT engages SIRT1 in cells to restrain the P53-CASPASE-3 apoptotic program in osteoblasts and mitigate estrogen-deficiency bone loss in OVX mice.
Authors
- Xueqin Hu (ORCID: https://orcid.org/0000-0003-2108-762X)
- Hongfeng Ruan (ORCID: https://orcid.org/0000-0001-8868-9313)
- Yishan Bian (ORCID: https://orcid.org/0000-0002-3938-1758)
- Yong‐Guan Zhu (ORCID: https://orcid.org/0000-0003-3861-8482)
- Chengliang Wu
- Qilan Wang (ORCID: https://orcid.org/0000-0002-3259-3301)
- Qixing Liang
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.intimp.2025.115820
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00