Synthesis of 4- and 5-Aminotriazolamers via Iterative Electrophilic Ethynylation and Azide–Alkyne Cycloaddition

Nonpeptidic foldamers derived from amino acids, i.e. 4- and 5-aminotriazolamers, were synthesized via the assembly of three amino acid-derived modules, which was achieved through the copper-catalyzed ethynylation with triisopropylsilyl ethynylbenziodoxolone and copper- or ruthenium-catalyzed azide-alkyne cycloadditions. The X-ray crystallographic analysis of cyclic 4- and 5-aminotriazolamers revealed their porous structure.