Association between visual hallucinations and α‐synuclein oligomers in patients with dementia with Lewy bodies
Visualization of αSYN oligomers by PLA and quantitative neuropathologic analysis. Abundant αSYN oligomers in parahippocampal cortex of DLB with VHs. First human brain study linking αSYN oligomers to VHs. Potential oligomer-targeted therapy for managing VH in DLB.
Authors
- Pamela J. McLean (ORCID: https://orcid.org/0000-0003-4870-5715)
- Christian Lachner (ORCID: https://orcid.org/0000-0002-1801-9768)
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Michael DeTure (ORCID: https://orcid.org/0000-0002-4363-1262)
- Daisuke Ono (ORCID: https://orcid.org/0000-0002-0238-7355)
- Tanis J. Ferman (ORCID: https://orcid.org/0000-0001-8377-6194)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- Owen A. Ross (ORCID: https://orcid.org/0000-0003-4813-756X)
- Hiroaki Sekiya (ORCID: https://orcid.org/0000-0001-9683-5966)
- L. Franke (ORCID: https://orcid.org/0000-0002-1970-1929)
Institutions
- Jacksonville College (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70904
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health