A posterior hypothalamic to midbrain circuit orchestrating nociceptive behaviours in male mice
Our results define a functional PH<sup>Glu</sup> → VTA<sup>DA</sup> → NAc circuit that contributes to chronic pain processing. Hyperactivity in this pathway facilitates nociceptive behaviours, while its inhibition exerts analgesic effects. Modulating this circuit may offer new therapeutic strategies for treating chronic pain.
Authors
- Weifeng Yu (ORCID: https://orcid.org/0000-0003-1979-6304)
- Dipesh Chaudhury (ORCID: https://orcid.org/0000-0001-8014-6373)
- Wei-Nan Zhao (ORCID: https://orcid.org/0009-0005-7158-6605)
- Po Gao (ORCID: https://orcid.org/0000-0002-2860-3239)
- Qi Li (ORCID: https://orcid.org/0000-0002-1759-9262)
- Fang Wang (ORCID: https://orcid.org/0000-0002-4781-8673)
- Song Zhang (ORCID: https://orcid.org/0000-0002-9786-802X)
- Hongzhi Liu (ORCID: https://orcid.org/0000-0002-1725-0976)
- Xiaodan Han (ORCID: https://orcid.org/0000-0002-2973-7343)
- Yu Ma (ORCID: https://orcid.org/0009-0008-4395-1240)
Institutions
- New York University Abu Dhabi (AE)
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Renji Hospital (CN)
- Huzhou Central Hospital (CN)
- Shanghai Cancer Institute (CN)
- Zhongshan Hospital (CN)
- Songjiang District Central Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai Sixth People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1111/bph.70227
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00