Phenyl Urea as an Aglet for Stabilizing <i>Trans</i> Proline: A Mimic of Ile–Phe Zipper
A phenyl urea unit is proposed as an aglet for completely favoring trans-Pro peptide bond, which is further stabilized by n → π* interaction. The urea-tagged Pro-Ile peptide is crystallized from nonaqueous solvent, and the X-ray structure analysis reveals self-assembly by clustering of hydrophobic side chains of Ile and phenyl ring, reminiscent of zipper structure found in coiled-coil peptides.
Authors
- V. Haridas (ORCID: https://orcid.org/0000-0002-2931-0585)
- Supriya Dwivedi
- Souvik Dutta
Institutions
- Indian Institute of Technology Palakkad (IN)
- Indian Institute of Technology Delhi (IN)
Publication Details
- Journal
- ChemBioChem
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1002/cbic.202500476
- Primary Topic
- Supramolecular Self-Assembly in Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.00