Simultaneous versus staged resection for conversion surgery in initially unresectable colorectal liver metastases: a multicenter prospective cohort study
This study provides compelling evidence that staged resection is the safer and more effective surgical strategy for patients with IU-CRLM achieving resectability through conversion therapy. With significantly lower complication rates and improved survival outcomes, these findings strongly support the adoption of staged resection in clinical practice. Randomized controlled trials are essential to confirm these results and refine treatment guidelines.
Authors
- Qing‐Hai Ye (ORCID: https://orcid.org/0000-0002-6724-4435)
- Songbin Lin
- Dexiang Zhu (ORCID: https://orcid.org/0000-0002-3168-2978)
- Xiaoying Wang (ORCID: https://orcid.org/0000-0002-3291-0725)
- Lechi Ye (ORCID: https://orcid.org/0000-0003-4818-6900)
- Wentao Tang (ORCID: https://orcid.org/0000-0002-8281-7588)
- Yijiao Chen
- Jianmin Xu (ORCID: https://orcid.org/0000-0002-5462-8421)
- Kaiyu Wang (ORCID: https://orcid.org/0000-0002-9300-7265)
- Li Ren (ORCID: https://orcid.org/0000-0003-0604-9166)
- Jue Zhang (ORCID: https://orcid.org/0000-0003-0440-1357)
- Junchang Zhu
- Pingping Xu (ORCID: https://orcid.org/0009-0009-7522-6585)
- Peng Zheng (ORCID: https://orcid.org/0009-0006-5105-7850)
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Huadong Hospital (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1097/js9.0000000000003982
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00