Strategic engineering of DNA aptamers as precision modulators in CRISPR-driven oncogene control
We developed a modular CRISPR signal conductor platform that leverages SaCas9-binding DNA aptamers for transcription factor-mediated logic operations and precise gene control. This system expands the toolkit for genetic circuit design and offers a promising strategy for targeted cancer gene therapy.
Authors
- Aolin Li (ORCID: https://orcid.org/0000-0003-0988-6787)
- Yonghao Zhan (ORCID: https://orcid.org/0000-0003-1282-2637)
- Chaojie Xu (ORCID: https://orcid.org/0000-0001-9609-1848)
- Cong Yin (ORCID: https://orcid.org/0000-0002-5175-6858)
- Zijian Zhao (ORCID: https://orcid.org/0009-0003-5837-9156)
- Sheng Li (ORCID: https://orcid.org/0000-0003-4070-7345)
- Yuchen Liu (ORCID: https://orcid.org/0000-0002-6517-0022)
- Tao Lu (ORCID: https://orcid.org/0000-0002-0013-4987)
- Chunyan Yang (ORCID: https://orcid.org/0000-0003-1580-4282)
- Congcong Cao (ORCID: https://orcid.org/0000-0003-3895-921X)
- Changning Lv
Institutions
- Peking University (CN)
- Hubei University of Chinese Medicine (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Peking University First Hospital (CN)
- Shenzhen University Health Science Center (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1097/js9.0000000000003837
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00