ANPEP as a potential mediator linking aspartame exposure to MAFLD: insights from network toxicology and multi-omics analyses
ANPEP was identified as a potential target that links aspartame exposure to MAFLD, and was further associated with inflammation, lipid dysregulation, and fibrosis. These findings suggest that aspartame may not represent a safe strategy for weight management and could increase the risk of liver injury and MAFLD progression.
Authors
- Yanjie Lin (ORCID: https://orcid.org/0000-0002-5167-7121)
- Q. Robert Yan (ORCID: https://orcid.org/0009-0009-6776-7947)
- Shengliang Xin
- Wenjing Wang (ORCID: https://orcid.org/0000-0002-4527-1168)
- Chi Zhang (ORCID: https://orcid.org/0009-0002-4479-5792)
- Xueying Li (ORCID: https://orcid.org/0000-0002-1471-7948)
- Yan Wang (ORCID: https://orcid.org/0000-0002-3477-1458)
- Long Xu (ORCID: https://orcid.org/0000-0002-9286-2876)
- Yuan Hong (ORCID: https://orcid.org/0000-0003-1731-5941)
- X. Fu (ORCID: https://orcid.org/0009-0001-3231-7729)
- Guiqiang Wang
- Jinwen Ma (ORCID: https://orcid.org/0009-0006-5861-1957)
- Jiandan Qian (ORCID: https://orcid.org/0000-0002-0112-7500)
- Wanwan Shi (ORCID: https://orcid.org/0000-0003-4730-4610)
Institutions
- Peking University (CN)
- Peking University First Hospital (CN)
- Peking University International Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1097/js9.0000000000004068
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00