Universal screening for Lynch syndrome and molecular classification of patients with endometrial cancer
This study confirms the effectiveness of NGS in identifying germline variants within a Chinese cohort of patients with EC, revealing an LS prevalence of 7.3%. Relying solely on MMR-IHC or MSI testing could lead to missed diagnoses of LS. Our findings contribute to a better understanding of the mutational landscape and prevalence of LS.
Authors
- Guangwei Yan (ORCID: https://orcid.org/0000-0002-9859-7727)
- Tengfei Wang (ORCID: https://orcid.org/0000-0002-1253-0514)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-0875-263X)
- Pei Zhang (ORCID: https://orcid.org/0000-0002-9986-0654)
- Xianxu Zeng (ORCID: https://orcid.org/0000-0002-0457-9908)
- Yushan Cao
Institutions
- Zhengzhou University (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1097/js9.0000000000003945
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00