Association Between Maternal IBD-Related Antibodies and Early Life Gut Inflammatory Status and Microbiota Composition: Insights from Cord Blood
Our findings suggest that maternal IBD-associated antibodies cross the placenta barrier and may be associated with intestinal inflammation and imbalanced microbiota colonization. Whether these serological profiles negatively influence the priming of the baby's immune system or IBD risk later in life remains to be determined.
Authors
- Manasi Agrawal (ORCID: https://orcid.org/0000-0003-4729-1485)
- Mellissa Picker
- Ariella Bar‐Gil Shitrit (ORCID: https://orcid.org/0000-0002-6946-4159)
- James L. Stone (ORCID: https://orcid.org/0000-0002-3724-7555)
- Anketse Debebe
- Dermot McGovern (ORCID: https://orcid.org/0000-0001-5621-759X)
- María Manuela Estevinho (ORCID: https://orcid.org/0000-0001-7171-0139)
- Siew C. Ng (ORCID: https://orcid.org/0000-0002-6850-4454)
- Paola Nicoletti
- Rhiannon Dutra-Clarke
- Isabella Nguyen (ORCID: https://orcid.org/0000-0002-0217-0324)
- Inga Peter
- Joana Torres
- Courtney S. Young (ORCID: https://orcid.org/0000-0001-9778-876X)
- Taegyu Kim (ORCID: https://orcid.org/0000-0002-6310-5323)
- Leonid Tarassishin (ORCID: https://orcid.org/0000-0002-2649-5465)
- Lin Zhang (ORCID: https://orcid.org/0000-0003-0424-9965)
- Jean–Frédéric Colombel
Institutions
- Cedars-Sinai Medical Center (US)
- Chinese University of Hong Kong (HK)
- Universidade do Porto (PT)
- Hebrew University of Jerusalem (IL)
- Shaare Zedek Medical Center (IL)
- Hospital Beatriz Ângelo (PT)
- Centro Hospitalar de Vila Nova de Gaia (PT)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/jir.s557581
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Bristol-Myers Squibb
- Leona M. and Harry B. Helmsley Charitable Trust
- Chiesi Farmaceutici
- Crohn's and Colitis Foundation
- Georgia Clinical and Translational Science Alliance
- Astellas Pharma
- Hong Kong Government
- National Institutes of Health
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences