Myxoid glioneuronal tumor with PDGFRA p.K385 mutation in the periventricular white matter: a rare case and literature insights

Dear Editor, We report the case of a 29-year-old man who presented with severe headache. MRI revealed an oval, well-defined lesion (12×18 mm) in the left periventricular white matter, hyperintense on T2-weighted imaging without contrast enhancement or edema. Gross total resection was performed. Brain and brainstem MRI revealed, in the left frontal region, an ovoid-shaped lesion measuring approximately 12×18 mm in axial dimensions, exhibiting a ‘target-like’ appearance. On FLAIR sequences, the lesion showed peripheral hyperintensity with a centrally hypointense area. The lesion margins appeared well-defined, and the core demonstrated high signal intensity on T2-weighted images (Fig. 1A) and hypointensity on FLAIR sequences.