Efficacy and Safety of Sublingual and Subcutaneous Immunotherapy in Children with Allergic Rhinitis: A Systematic Review of Randomized Trials Including Direct and Indirect Comparisons
Both SLIT and SCIT are effective for pediatric AR. SLIT offers comparable efficacy for many outcomes with better safety/convenience, while SCIT may have advantages for certain outcomes but requires clinic administration. Treatment choice requires individualization based on efficacy, safety, adherence potential, and patient/family factors. Further high-quality, long-term comparative trials are needed.
Authors
- Ashwag Asiri (ORCID: https://orcid.org/0000-0001-5141-2804)
- Faris Alzahrani (ORCID: https://orcid.org/0000-0001-6306-8342)
- Gawaher Mohammed Ismail
- Shymaa Abdullah Althubaiti
- Lina Mansour Alzhrani (ORCID: https://orcid.org/0009-0001-8263-4044)
- Nora Almonawar (ORCID: https://orcid.org/0009-0002-1466-7925)
- Wamidh Alkhalifah
- Raneem Albeladi
- Osama Mater Almutairi
- Rayan Abdullah Alsaqri
Institutions
- Qassim University (SA)
- Taif University (SA)
- King Saud bin Abdulaziz University for Health Sciences (SA)
- Ibn Sina National College for Medical Studies (SA)
- Armed Forces Hospital (SA)
- King Khaled Hospital (SA)
- King Khalid University (SA)
- Alexandria University (EG)
Publication Details
- Journal
- International Journal of General Medicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/ijgm.s547338
- Citations
- 2
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 3.24