Tetrahedral DNA Nanostructures as a Multifactorial Nanotherapeutic Platform for Deep Vein Thrombosis: Targeting Necroptosis, Oxidative Stress, and Inflammation
These findings underscore TDNs' potential as a safe and effective nanotherapeutic platform for managing DVT by simultaneously targeting necroptosis, oxidative stress, and inflammation. Future studies are warranted to optimize dosing strategies and evaluate their long-term safety and synergistic use with established anticoagulants.
Authors
- Yunyan Li (ORCID: https://orcid.org/0000-0002-1713-342X)
- Yongping Lu (ORCID: https://orcid.org/0000-0001-8762-3531)
- Hanning Yang
- Yinghua Lv (ORCID: https://orcid.org/0000-0001-8241-399X)
- Wenjing Cao (ORCID: https://orcid.org/0000-0002-1831-349X)
- Lirong Xu
Institutions
- Yunnan University (CN)
- Kunming Medical University (CN)
- Second People's Hospital of Yunnan Province (CN)
- Dali University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/ijn.s534411
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00