TOP2A promotes non-small cell lung cancer progression via LDHA-mediated glycolysis and histone lactylation

Our results indicate a new function for <i>TOP2A</i> in promoting NSCLC progression through modulating glycolysis and histone lactylation, suggesting <i>TOP2A</i> as a possible therapeutic target to treat NSCLC.

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Publication Details

Journal
Translational Cancer Research
Published
2025-10-01
DOI
https://doi.org/10.21037/tcr-2025-702
Citations
1
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
1.52
Controls
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article

TOP2A promotes non-small cell lung cancer progression via LDHA-mediated glycolysis and histone lactylation

Qiong Wu, Feng Hu, Weiqin Wang, Fan Ye
1 citations
Translational Cancer Research
Lung Cancer Treatments and Mutations
1.52
article

TOP2A promotes non-small cell lung cancer progression via LDHA-mediated glycolysis and histone lactylation

Qiong Wu, Feng Hu, Weiqin Wang, Fan Ye
article en
1 citations

Abstract

Our results indicate a new function for <i>TOP2A</i> in promoting NSCLC progression through modulating glycolysis and histone lactylation, suggesting <i>TOP2A</i> as a possible therapeutic target to treat NSCLC.

Translational Cancer ResearchVol. 14(10)
Shanghai Jiao Tong University (CN), Tongren Hospital (CN)
Openalex Percentile: Top 13%
Lung Cancer Treatments and Mutations
1.52
DOIOpen Access PDFOpenAlex
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TOP2A promotes non-small cell lung cancer progression via LDHA-mediated glycolysis and histone lactylation — Qiong Wu, Feng Hu, et al. · Translational Cancer Research (2025) | TGRS Research Map | TGRS