Loss of Slc39a5 in α-cells impairs glucose metabolism by chronically increasing glucagon
These results demonstrate that Slc39a5 deficiency in α-cells leads to chronic glucagon elevation, which directly impairs hepatic glucose metabolism and promotes insulin resistance and hyperglycemia. This study thus establishes a causal role for α-cells Slc39a5 in prediabetes progression, highlighting sustained glucagon excess as a key contributor of metabolic dysfunction.
Authors
- Jing Ren (ORCID: https://orcid.org/0000-0003-1317-1696)
- Rui‐Ping Xiao (ORCID: https://orcid.org/0000-0003-2448-409X)
- Xiuqin Zhang (ORCID: https://orcid.org/0000-0001-8692-7146)
- Xueting Sun
- Wenyong Xiong (ORCID: https://orcid.org/0000-0001-9174-3667)
- Ning Hou (ORCID: https://orcid.org/0000-0001-5494-8460)
- Xuelian Wang (ORCID: https://orcid.org/0000-0003-0671-5958)
- Wenli Chen (ORCID: https://orcid.org/0000-0002-2379-4005)
- Yan Xu (ORCID: https://orcid.org/0000-0001-7953-6737)
- Weiyi Cui
Institutions
- Yunnan University (CN)
- Peking University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jare.2025.11.013
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00