Targeting the LPS-STING axis: neomycin restores STING-mediated anti-tumor immune suppression and inhibits tumor growth
Our findings demonstrate that elevated LPS in the TME inhibits anti-tumor innate immunity by impairing macrophage function. The combination of LPS modulation via neomycin with innate immune activation via STING agonists presents a potential strategy to enhance tumor immunotherapy.
Authors
- Chenglin Ye (ORCID: https://orcid.org/0000-0001-5646-2405)
- Kailang Wu (ORCID: https://orcid.org/0000-0002-0926-9300)
- Hong Fan (ORCID: https://orcid.org/0000-0003-4518-8775)
- Mingfu Tian (ORCID: https://orcid.org/0000-0003-0122-6397)
- Zhiqiang Li (ORCID: https://orcid.org/0000-0002-7187-8190)
- Siyu Liu (ORCID: https://orcid.org/0000-0002-9455-202X)
- Chengliang Zhu (ORCID: https://orcid.org/0000-0002-1120-4418)
- Dongjie Fu
Institutions
- Wuhan University (CN)
- Wuhan Institute of Virology (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1637667
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00