CST7+ macrophages/monocytes in melanoma: single-cell insights into immunotherapy response
These findings suggest that CST7<sup>+</sup> macrophages/monocytes are associated with immunotherapy response by correlating with cytotoxic T-cell activation through the ICOSL/ICOS pathway. The observed interaction highlights the potential for combining immune checkpoint inhibitors (ICIs) with ICOS/ICOSL agonistic antibodies to enhance and sustain long-term immunotherapy efficacy in patients with melanoma.
Authors
- Gang Zhou (ORCID: https://orcid.org/0000-0003-4988-0814)
- Zhan‐Lin Li (ORCID: https://orcid.org/0000-0001-5306-3396)
- Yan Li (ORCID: https://orcid.org/0000-0002-9402-1093)
- Liuqing Zheng (ORCID: https://orcid.org/0009-0003-6324-3595)
- Fan Wu (ORCID: https://orcid.org/0000-0002-1328-7915)
- Daiwei Liu (ORCID: https://orcid.org/0000-0002-2294-4323)
- Jing Li (ORCID: https://orcid.org/0000-0003-2504-1629)
- Yang Liu (ORCID: https://orcid.org/0000-0002-9442-700X)
- Boying Zheng
- Kaitao Yao (ORCID: https://orcid.org/0000-0002-8422-4620)
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-1943
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00