CXCR3 enhanced murine chimeric antigen receptor T cells in the treatment of solid tumors
CXCR3 overexpression potentiates the anti-tumor capacity of CAR-Ts in solid tumors by enhancing tumor infiltration. This strategy provides a promising approach for overcoming the current limitations of CAR-T therapy.
Authors
- Qinggang Xu (ORCID: https://orcid.org/0000-0002-8659-7041)
- Feng Yu (ORCID: https://orcid.org/0000-0002-1929-3881)
- Qiang Wang (ORCID: https://orcid.org/0000-0003-2614-9201)
- Xiangzhi Zhang (ORCID: https://orcid.org/0000-0003-2223-2761)
- Xiaoyan Wang
- Luyu Zhu
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-1920
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05