Impact of oxygen deprivation on the FLASH effect for skin toxicity in a murine model
Our findings suggest that oxygen availability is required for the normal tissue sparing associated with FLASH irradiation, and during hypoxia the FLASH DMF was reversed.
Authors
- Jacob Johansen (ORCID: https://orcid.org/0000-0001-8475-0447)
- Line Kristensen (ORCID: https://orcid.org/0000-0003-0924-475X)
- Axel Kornerup Hansen (ORCID: https://orcid.org/0000-0003-1575-2507)
- P.R. Poulsen (ORCID: https://orcid.org/0000-0001-9940-7609)
- Valentin Vacari Møller
- Priyanshu M. Sinha (ORCID: https://orcid.org/0000-0001-6115-1556)
- Brita Singers Sørensen
Institutions
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1016/j.radonc.2025.111277
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00