Tumor-intrinsic dichotomy shapes cellular heterogeneity in pancreatic cancer
Intratumoral heterogeneity in pancreatic cancer poses a significant challenge, contributing to disease aggressiveness and complicating treatment. A recent study by Li et al. reveals that this heterogeneity is maintained by tumor-intrinsic reciprocal signaling between SPP1 and GREM1 in the epithelial and mesenchymal cell populations of pancreatic cancer.
Authors
- Shiv K. Singh (ORCID: https://orcid.org/0000-0002-5725-4058)
- R. D. Sudhaker Samuel
Institutions
- Universitätsmedizin Göttingen (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Trends in cancer
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.trecan.2025.11.003
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe