Xingshen Jieyu Decoction ameliorates post-stroke depression by modulating proBDNF/BDNF signaling via PI3K/Akt pathway
XSJY alleviates depressive-like behaviors in PSD rats by attenuating hippocampal apoptosis(most notably in DG) and restoring neurotrophic balance. Its actions are mediated partly via PI3K/Akt and proBDNF/BDNF signaling, with additional pathways likely contributing to its multi-target neuroprotective effects.
Authors
- Wei Zhao (ORCID: https://orcid.org/0000-0003-2421-7311)
- Zhenxiang Han (ORCID: https://orcid.org/0000-0003-1963-580X)
- L. Li
- Hongpu Song (ORCID: https://orcid.org/0000-0003-4941-9200)
- Zhao-Yu Hou
- Jian‐Yong Zhu (ORCID: https://orcid.org/0000-0001-5922-9326)
- Yang Yang (ORCID: https://orcid.org/0000-0002-0536-8416)
- Honglin Wang (ORCID: https://orcid.org/0000-0001-6302-6927)
- Xiang Chen (ORCID: https://orcid.org/0009-0004-4005-9549)
- Yu Lou (ORCID: https://orcid.org/0000-0002-2015-3501)
- Yue Zhu
- Zeyu Ren
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Nanjing University of Chinese Medicine (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Jining University (CN)
- Yueyang Hospital (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Seventh People's Hospital of Shanghai (CN)
- Jinhua University of Vocational Technology (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1016/j.jep.2025.120884
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00