Nicotinic Acetylcholine Receptor Pathways in Cancer: From Psychiatric Clues to Therapeutic Opportunities
These findings underscore the importance of targeting nAChRs in a context-specific manner to modulate shared signaling pathways, particularly the acetylcholine-stimulated Src/MAPK pathway. This review also calls for more investigation on other neurotransmitters and potential common pathways, as implicated by psychological reports, to advance the understanding of cancer biology and therapies.
Authors
- Pouya Pazooki (ORCID: https://orcid.org/0000-0002-8609-5949)
- Soheila Ajdary (ORCID: https://orcid.org/0000-0002-5052-2523)
- Hamed Shafaroodi (ORCID: https://orcid.org/0000-0001-6902-6020)
- M Azadi
Institutions
- Pasteur Institute of Iran (IR)
- University of Calgary (CA)
- Kharazmi University (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Cancer Reports
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/cnr2.70387
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00