NSD2 mediates NF-κB and matrix metalloproteinases to drive hepatocellular carcinoma malignant progression
In summary, NSD2 acts as a tumorigenic factor in the progression of HCC by activating the NF-κB and MMPs signalling pathways.
Authors
- Hengjing He (ORCID: https://orcid.org/0000-0002-1448-5585)
- Di Xiao (ORCID: https://orcid.org/0000-0003-2419-7840)
- Xiaoxing Huang (ORCID: https://orcid.org/0000-0002-9451-9369)
- Yufei Lei (ORCID: https://orcid.org/0000-0002-5467-3687)
- Xingruo Zeng (ORCID: https://orcid.org/0000-0001-9113-9611)
- Xinran Li (ORCID: https://orcid.org/0000-0001-8988-7223)
- Qiuping Zhang (ORCID: https://orcid.org/0000-0002-2633-5824)
- Qianshan Ding (ORCID: https://orcid.org/0000-0002-9989-6876)
- Liang Shao (ORCID: https://orcid.org/0000-0001-9066-8503)
- Muhammad Jamal (ORCID: https://orcid.org/0000-0002-5625-4021)
- Yingjie Wu (ORCID: https://orcid.org/0000-0001-8326-4973)
- Meng Xiong (ORCID: https://orcid.org/0009-0007-2602-769X)
Institutions
- Wuhan University (CN)
- Northwest University (CN)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Hubei Engineering University (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.21037/tcr-2025-799
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00