Uracil in plasma: comparison of two in-house-developed LC-MS/MS methods

For the analysis of uracil, both presented methods, which are based on simplified sample preparation procedures, provide accurate results without significantly impacting the clinical interpretation. However, the results indicate a potential gray area of analytical imprecision from 14 to 20 μg/L, encompassing the lower clinical decision limit (16 μg/L).

Authors

Institutions

Publication Details

Journal
Clinical Chemistry and Laboratory Medicine (CCLM)
Published
2025-11-15
DOI
https://doi.org/10.1515/cclm-2025-0782
Primary Topic
Urinary Tract Infections Management
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Uracil in plasma: comparison of two in-house-developed LC-MS/MS methods

Eva Greibe, Svend Høime Hansen
Clinical Chemistry and Laboratory Medicine (CCLM)
Urinary Tract Infections Management
article

Uracil in plasma: comparison of two in-house-developed LC-MS/MS methods

Eva Greibe, Svend Høime Hansen
article en

Abstract

For the analysis of uracil, both presented methods, which are based on simplified sample preparation procedures, provide accurate results without significantly impacting the clinical interpretation. However, the results indicate a potential gray area of analytical imprecision from 14 to 20 μg/L, encompassing the lower clinical decision limit (16 μg/L).

Clinical Chemistry and Laboratory Medicine (CCLM)Vol. 64(4)
Aarhus University (DK), Aarhus University Hospital (DK), Copenhagen University Hospital (DK), Rigshospitalet (DK)
Aarhus Universitet, Aarhus Universitetshospital, Gentofte Hospital, Rigshospitalet
Openalex Percentile: Top 55%
Urinary Tract Infections Management
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.