A novel homozygous <i>KEL</i> variant causing K <sub>0</sub> phenotype in a Chinese woman and therapeutic plasma exchange for anti‐Ku removal in preoperative management
We identified a novel homozygous KEL variant causing K<sub>0</sub> phenotype in a Chinese woman with Ku alloimmunization. TPE proved to be effective for decreasing anti-Ku titers. However, the rebound of antibodies should be considered when using TPE to decrease the antibody titers. This report demonstrates a new attempt in preoperative transfusion management for patients with rare alloantibodies.
Authors
- Aijing Li
- Xinfang Zhu
- Danxin Du (ORCID: https://orcid.org/0009-0004-6446-6042)
- Ziyan Zhu (ORCID: https://orcid.org/0000-0001-9407-7727)
- J. W. Zheng
- Zhicheng Wang
- Dandan Li (ORCID: https://orcid.org/0000-0001-9346-3212)
- Rong Xia (ORCID: https://orcid.org/0000-0002-2463-6340)
- Dong Xiang (ORCID: https://orcid.org/0000-0001-8989-1476)
Institutions
- Fudan University (CN)
- Shanghai Blood Center (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Transfusion
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1111/trf.18444
- Citations
- 1
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77