B-cell lymphoma-extra large expression correlated with protein kinase RNA-like ER kinase and ubiquitination signals in the type 1 diabetes mouse model
This study uncovers a new neuropathology underlying T1DM-associated DN: Bcl-<sub>XL</sub> activation associates PERK and ubiquitination marker upregulation in sensory neurons. Bcl-<sub>XL</sub> inactivation in nociceptors might be a potential target for relieving neuropathic pain of T1DM.
Authors
- Ying‐Shuang Chang
- Yu‐Lin Hsieh (ORCID: https://orcid.org/0000-0002-6380-3455)
- Tzu-Ning Chao
- Yu‐Yu Kan
Institutions
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
Publication Details
- Journal
- PAIN Reports
- Published
- 2025-11-11
- DOI
- https://doi.org/10.1097/pr9.0000000000001356
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00