Wogonin, a bioactive flavonoid from Scutellaria baicalensis, alleviates alcoholic pancreatitis via AMPK-mediated TFEB activation
This study establishes Wogonin as the pivotal bioactive driver behind HQ's therapeutic efficacy, orchestrating AMPK-TFEB-autophagy coordination to mitigate AP. Atomic-level resolution of Wogonin's adenine-mimetic binding to AMPK provides novel therapeutic strategies for developing kinase-stabilizing botanicals targeting TFEB activation to treat pancreatitis.
Authors
- Zhongxiang Zhao (ORCID: https://orcid.org/0000-0001-6991-5805)
- Xiaohong Sun
- Zhongqiu Liu (ORCID: https://orcid.org/0000-0001-6986-9677)
- Caiyan Wang (ORCID: https://orcid.org/0000-0002-8605-2340)
- Xiaojuan Chao (ORCID: https://orcid.org/0000-0002-8731-7785)
- Shaogui Wang (ORCID: https://orcid.org/0000-0002-2281-6620)
- Liming Wang (ORCID: https://orcid.org/0000-0002-5444-2424)
- Haixia Wang (ORCID: https://orcid.org/0000-0002-5782-8242)
- Lin An (ORCID: https://orcid.org/0000-0003-1353-2092)
- Jinping Wang (ORCID: https://orcid.org/0000-0003-4325-9939)
- Zhen Qin (ORCID: https://orcid.org/0009-0000-0388-8840)
- Shujun Chen (ORCID: https://orcid.org/0000-0003-0999-5203)
- Guorong Li (ORCID: https://orcid.org/0000-0003-4457-3380)
- Xiaowen Ma (ORCID: https://orcid.org/0000-0001-9324-0350)
- Shiyun Tan
- Jing-min Zeng
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Hunan University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shenzhen Children's Hospital (CN)
- Shenzhen Second People's Hospital (CN)
- Newcastle University (GB)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.jare.2025.11.006
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00