APE1 mediates chemoresistance in esophageal squamous cell carcinoma by remodeling the immunosuppressive microenvironment
High APE1 expression is an independent predictor of poor prognosis in ESCC patients receiving postoperative chemotherapy, associated with Treg and CAFs-mediated immunosuppression. APE1 serves as a prognostic biomarker linked to immunosuppression, enabling personalized adjuvant therapy.
Authors
- Xunjie Kuang
- Xiuyong Liao
- Jianhua Rao (ORCID: https://orcid.org/0000-0003-1222-7707)
- Yong Wang (ORCID: https://orcid.org/0000-0003-4505-9690)
- Dong Wang (ORCID: https://orcid.org/0000-0002-7446-4604)
- Yuxin Yang (ORCID: https://orcid.org/0000-0001-7398-7473)
- He Xiao
- Yujing Yao
- Mengxia Li (ORCID: https://orcid.org/0009-0007-9987-7302)
- H. Gao (ORCID: https://orcid.org/0009-0006-4207-0818)
Institutions
- Army Medical University (CN)
- Chongqing University (CN)
- Daping Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1689468
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Chongqing