Longitudinal plasma proteomics: relation to incident Alzheimer's disease dementia and biomarkers
Changes in plasma ACES and IGFALS linked to baseline AD cognitive stages Changes in ACES, C7, ZCD1, IL-17C, CC055, and SO5A1 associated with incident ADD Changes in those proteins correlated with baseline AD imaging and plasma biomarkers Proteomics model achieved 84.8% AUC-ROC in predicting incident ADD.
Authors
- Donna M. Wilcock (ORCID: https://orcid.org/0000-0003-3388-1564)
- Shannon L. Risacher (ORCID: https://orcid.org/0000-0002-3304-7943)
- Changgee Chang (ORCID: https://orcid.org/0000-0003-3426-1295)
- Andrew J. Saykin (ORCID: https://orcid.org/0000-0002-1376-8532)
- Nicholas K. Adzibolosu (ORCID: https://orcid.org/0000-0002-3829-5786)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Tamina Park
- Sujuan Gao (ORCID: https://orcid.org/0000-0002-6741-6380)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Eun Hye Lee (ORCID: https://orcid.org/0000-0001-8090-6571)
- Taeho Jo (ORCID: https://orcid.org/0000-0001-7448-9433)
- Paula J. Bice (ORCID: https://orcid.org/0000-0001-5357-9966)
- Soumilee Chaudhuri (ORCID: https://orcid.org/0000-0002-8488-6114)
- Jared R. Brosch (ORCID: https://orcid.org/0000-0002-6578-0584)
- Kwangsik Nho (ORCID: https://orcid.org/0000-0002-7624-3872)
- Yen‐Ning Huang
- Shiwei Liu
Institutions
- Indiana University Health (US)
- Neurosciences Institute (US)
- Indiana University School of Medicine
- Wake Forest University (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70900
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Ghana National Petroleum Corporation
- National Institutes of Health
- National Institute on Aging