Tubastatin A alleviates post-resuscitation myocardial damage possibly via inhibiting GSDME-mediated pyroptosis and MLKL-mediated necroptosis in a porcine model of cardiac arrest
TubA could effectively alleviate post-resuscitation myocardial damage in a porcine model of CA and resuscitation, in which the protective role was possibly related to the inhibition of GSDME-mediated pyroptosis and MLKL-mediated necroptosis.
Authors
- Xue Zhao
- Jiefeng Xu (ORCID: https://orcid.org/0000-0001-5597-0838)
- Yixuan Fang (ORCID: https://orcid.org/0000-0003-1167-0598)
- Linjie Lai
- Pin Lan (ORCID: https://orcid.org/0009-0000-0374-218X)
- Lutao Xie
Institutions
- Key Laboratory of Guangdong Province (CN)
- Lishui Central Hospital (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Resuscitation Plus
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.resplu.2025.101158
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00