Genetic characterization of pediatric B-cell acute lymphoblastic leukemia in Argentina uncovers molecular heterogeneity and novel variants
This study not only reports transcriptional heterogeneity in our Latin American cohort but also supports the implementation of open-source bioinformatic pipelines in resource-limited settings to enhance precision diagnosis and guide personalized treatment.
Authors
- Daniel Avendaño
- Luis Aversa
- Geraldine Gueron (ORCID: https://orcid.org/0000-0002-9283-7451)
- Ezequiel Sosa (ORCID: https://orcid.org/0000-0002-7925-8973)
- Javier Cotignola (ORCID: https://orcid.org/0000-0003-4473-9854)
- Cecilia Riccheri
- Virginia Schuttenberg
- Elba S. Vázquez (ORCID: https://orcid.org/0000-0002-0460-0236)
- María Sol Ruiz (ORCID: https://orcid.org/0000-0001-9008-3302)
- María Laura Lacreu
- Ignacio Gomez Mercado
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Buenos Aires (AR)
- Hospital de Niños Superiora Sor María Ludovica (AR)
- Hospital Posadas (AR)
- Hospital General de Niños Ricardo Gutierrez (AR)
- Fundación Ciencias Exactas y Naturales (AR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-11-17
- DOI
- https://doi.org/10.3389/fphar.2025.1701680
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00