Developmental properties of parvalbumin-positive gamma-aminobutyric acid interneurons and the effect of fluoxetine treatment and binocular form deprivation on them in the visual cortex of adult rats
The number of PV-positive neurons and PNNs-surrounded PV neurons in the rat visual cortex increases postnatally and reaches adult levels by postnatal week 7. Chronic FLX treatment downregulates these expressions. Combined 4-week FLX treatment and BFD exerts a more significant inhibitory effect on the PNNs<sup>+</sup>/PV<sup>+</sup>/total PV<sup>+</sup> ratio than either intervention alone.
Authors
- Lai-Qing Xie
- Xiaodong Wen (ORCID: https://orcid.org/0000-0001-5626-8581)
- Manhui Zhu (ORCID: https://orcid.org/0000-0002-3396-0222)
- Xiaoyan Ji (ORCID: https://orcid.org/0000-0002-8044-2276)
- Yang Guo (ORCID: https://orcid.org/0000-0001-9830-5942)
- Yiqian Xu
- Qiaoyun Wang (ORCID: https://orcid.org/0000-0003-4801-8085)
- Gengzhe Shen
Institutions
- Jiangsu University (CN)
- Nanjing University of Chinese Medicine (CN)
- Soochow University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- First People's Hospital of Kunshan (CN)
- Traditional Chinese Medicine Hospital of Kunshan (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Suzhou Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- International Journal of Ophthalmology
- Published
- 2025-11-17
- DOI
- https://doi.org/10.18240/ijo.2025.12.03
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00