Aberrant sialic acid metabolism promotes metabolic reprogramming and metastasis in breast cancer
This study collectively elucidates the role of Neu5Ac metabolism in promoting breast cancer invasion and metastasis through the remodeling of lipid metabolic pathways and alterations in protein sialylation. The findings present novel evidence supporting the targeting of sialic acid metabolism and its modifications as potential therapeutic strategies for inhibiting tumor progression.
Authors
- Chunyan Dong (ORCID: https://orcid.org/0000-0003-2392-3185)
- Meijin Wang
- Longyu Yang
- Zhenhua Li (ORCID: https://orcid.org/0000-0001-9751-0864)
- Shilin Zhang (ORCID: https://orcid.org/0000-0002-5872-3418)
- Li Fu (ORCID: https://orcid.org/0009-0005-0045-7750)
- Zengqi Man
- Xing Xiong
Institutions
- Tongji University (CN)
- Weifang Medical University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- ShanghaiTech University (CN)
- Weifang People's Hospital (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-17
- DOI
- https://doi.org/10.3389/fonc.2025.1698087
- Citations
- 1
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.81