Associations between body mass index and lung function using Z-scores: a nonlinear relationship and machine learning classification modeling

This study reveals differential and opposing associations between BMI and ventilatory impairment phenotypes, with higher BMI inversely associated with obstructive defects but positively associated with restrictive defects. Moreover, strong correlations were validated through extensive adjustments and machine learning models.

Authors

Jiangjiang Liu (ORCID: https://orcid.org/0000-0002-1341-2763)
Yu Zhang (ORCID: https://orcid.org/0000-0003-3474-422X)
Wei Feng (ORCID: https://orcid.org/0000-0002-7667-4007)
Fei Lu (ORCID: https://orcid.org/0000-0003-4948-2672)
Haitao Ma (ORCID: https://orcid.org/0000-0003-3655-039X)
Shi-Yu Shen

Institutions

Soochow University (CN)

Publication Details

Journal: Frontiers in Physiology
Published: 2025-11-17
DOI: https://doi.org/10.3389/fphys.2025.1706759
Primary Topic: Chronic Obstructive Pulmonary Disease (COPD) Research
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Suzhou Municipal Science and Technology Bureau

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article

Associations between body mass index and lung function using Z-scores: a nonlinear relationship and machine learning classification modeling

Jiangjiang Liu, Yu Zhang, Wei Feng, Fei Lu et al.

Nov 17, 2025

Frontiers in Physiology

Chronic Obstructive Pulmonary Disease (COPD) Research

article

Associations between body mass index and lung function using Z-scores: a nonlinear relationship and machine learning classification modeling

Jiangjiang Liu, Yu Zhang, Wei Feng, Fei Lu, Haitao Ma, Shi-Yu Shen

November 17, 2025article en

Abstract

This study reveals differential and opposing associations between BMI and ventilatory impairment phenotypes, with higher BMI inversely associated with obstructive defects but positively associated with restrictive defects. Moreover, strong correlations were validated through extensive adjustments and machine learning models.

Frontiers in PhysiologyVol. 16

Soochow University (CN)

Suzhou Municipal Science and Technology Bureau

Openalex Percentile: Top 50%

Chronic Obstructive Pulmonary Disease (COPD) Research

DOI Open Access PDF OpenAlex

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Associations between body mass index and lung function using Z-scores: a nonlinear relationship and machine learning classification modeling — Jiangjiang Liu, Yu Zhang, et al. · Frontiers in Physiology (2025) | TGRS Research Map | TGRS