Remnant cholesterol shows inverse and nonlinear associations with leukocyte telomere length and serum α-Klotho, mediated by inflammation and oxidative stress
RC is inversely and nonlinearly associated with both LTL and α-Klotho, independent of traditional lipid profiles, with inflammation and oxidative stress as partial mediators. From an aging perspective, these cross-sectional findings support increased attention to early RC management alongside traditional lipids.
Authors
- Jie Yu (ORCID: https://orcid.org/0000-0003-1393-4227)
- Fan Ping (ORCID: https://orcid.org/0000-0001-7650-6612)
- Yuxiu Li (ORCID: https://orcid.org/0000-0002-5227-421X)
- Lingling Xu (ORCID: https://orcid.org/0009-0000-7544-5897)
- Baodi Xing (ORCID: https://orcid.org/0000-0002-8735-2505)
- Wei Li (ORCID: https://orcid.org/0000-0002-3332-1287)
- Shuli He
- Xinyue Chen (ORCID: https://orcid.org/0000-0001-8288-7685)
- Yiwen Liu (ORCID: https://orcid.org/0000-0002-7982-7996)
- Huabing Zhang (ORCID: https://orcid.org/0000-0001-8402-7830)
- Qi Gao (ORCID: https://orcid.org/0009-0009-0963-5567)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-11-17
- DOI
- https://doi.org/10.3389/fendo.2025.1700349
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00