The impact of weight loss in early pregnancy on the incidence of late gestational diabetes: a retrospective cohort study
First trimester WG is significantly associated with the occurrence of GDM. In contrast, there is only a minimal association between second-trimester and pre-OGTT WG and the risk of GDM. Inadequate first-trimester weight gain reduces GDM risk, especially in younger women, women with normal or low PPBMI, elevated fasting glucose, and low HDL or triglycerides, without increasing abnormal neonatal birth weight. Early pregnancy represents a critical window for GDM prevention. Minimal weight gain during this period may be a feasible and acceptable approach to reducing GDM risk.
Authors
- Qiuping Liao
- Ruiyun Chen (ORCID: https://orcid.org/0000-0002-0037-856X)
- Junping Shi (ORCID: https://orcid.org/0000-0001-9434-897X)
- Liping Huang (ORCID: https://orcid.org/0000-0002-1463-2768)
- Lin Lin (ORCID: https://orcid.org/0000-0001-6304-2249)
- Zihua Chen (ORCID: https://orcid.org/0000-0002-7356-9404)
- Huihui Huang (ORCID: https://orcid.org/0009-0000-9244-4319)
- Lianghui Zheng (ORCID: https://orcid.org/0009-0008-8829-669X)
- Jiaoxia Liu
Institutions
- Fujian Medical University (CN)
- Fuzhou Maternity and Child Health Care Hospital (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-11-17
- DOI
- https://doi.org/10.3389/fnut.2025.1688268
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00