Association of serum vascular endothelial growth factor-C, vascular endothelial growth factor receptor-3, and insulin-like growth factor 1 levels with metastasis and prognosis in patients with nasopharyngeal carcinoma
Serum levels of VEGFC, VEGFR-3, and IGF1 are significantly correlated with metastasis and poor prognosis in NPC patients. These biomarkers, particularly when combined and integrated with EBV DNA load, serve as valuable indicators for predicting metastatic risk and assessing survival outcomes in NPC.
Authors
- Wulin Wen (ORCID: https://orcid.org/0009-0007-1530-7880)
- Le Wang (ORCID: https://orcid.org/0000-0002-0375-3177)
- Yutong Zhao
- Yongchun Li (ORCID: https://orcid.org/0009-0006-8395-6439)
- Jia Zhao (ORCID: https://orcid.org/0000-0001-9338-8910)
Institutions
- Yinchuan First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-11-17
- DOI
- https://doi.org/10.3389/fonc.2025.1655015
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Ningxia Province
- Key Research and Development Program of Ningxia