Hydrogen regulates the aryl hydrocarbon receptor, improving bronchopulmonary dysplasia in neonatal rats and RLE-6TN cells exposed to hyperoxia
H₂ alleviates ER stress and reduces apoptosis by regulating AHR and its downstream molecule CPEB4, thereby mitigating hyperoxia-induced BPD. The protective mechanism of H₂ may be closely associated with the modulation of the AHR-CPEB4 signaling pathway and the attenuation of ER stress.
Authors
- Hang Hubert Yin (ORCID: https://orcid.org/0000-0002-9762-4818)
- Jin Wang (ORCID: https://orcid.org/0000-0002-7873-4384)
- Chunli Yang
- Mulin Liang (ORCID: https://orcid.org/0000-0002-0463-011X)
- Wei Zhou (ORCID: https://orcid.org/0000-0003-1060-3633)
- Feifei Song
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-11-17
- DOI
- https://doi.org/10.3389/fped.2025.1662922
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province