Clinical Implications of Ki‐67 Index, Grade and Hormonal Changes in Pancreatic Neuroendocrine Tumors: Insights Into Tumor Heterogeneity Based on Primary and Secondary Lesions
A subset of PanNETs exhibited increased proliferation of metastases or recurrence without detrimental survival effects, possibly because of timely treatment adjustments. Rebiopsy may be useful for detecting proliferative changes, whereas hormonal shifts highlight tumor heterogeneity and warrant continued clinical and biochemical monitoring.
Authors
- Nao Fujimori (ORCID: https://orcid.org/0000-0003-4286-8804)
- Keijiro Ueda (ORCID: https://orcid.org/0000-0003-1119-9986)
- Yoshinao Oda (ORCID: https://orcid.org/0000-0001-9636-1182)
- Masatoshi Murakami (ORCID: https://orcid.org/0000-0002-8791-0052)
- Yoshihiro Ogawa (ORCID: https://orcid.org/0000-0002-0834-2836)
- Tetsuhide Ito (ORCID: https://orcid.org/0000-0001-5381-0136)
- Kohei Nakata (ORCID: https://orcid.org/0000-0002-5717-8569)
- Kazuhide Matsumoto (ORCID: https://orcid.org/0000-0003-0842-6500)
- Masafumi Nakamura
- Takeo Yamamoto
Institutions
- Kyushu University (JP)
- Fukuoka International University (JP)
- Fukuoka Hospital (JP)
- Fukuoka Kinen Hospital (JP)
- Sanno Medical Center (JP)
- International University of Health and Welfare (JP)
Publication Details
- Journal
- Journal of Hepato-Biliary-Pancreatic Sciences
- Published
- 2025-11-16
- DOI
- https://doi.org/10.1002/jhbp.70028
- Citations
- 1
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Japan Society for the Promotion of Science