Not just the medial temporal lobe: Precuneus and posterior cingulate volumes relate to plasma biomarkers and cognition in a sub‐Saharan African cohort
First biomarker-neuroimaging study of dementia in sub-Saharan Africa (SSA). Lower amyloid-beta (Aβ) 42/40 linked to reduced posterior cingulate volumes. Higher plasma NfL associated with right precuneus and PCC atrophy. Posterior cingulate atrophy predicted memory and executive dysfunction. Study supports plasma biomarkers for AD screening in SSA settings.
Authors
- Jean N. Ikanga (ORCID: https://orcid.org/0000-0001-8754-733X)
- Maria Misiura (ORCID: https://orcid.org/0000-0002-8390-5950)
- Alexandria Bartlett (ORCID: https://orcid.org/0000-0001-7020-9852)
- Jeni L. Burnette (ORCID: https://orcid.org/0000-0001-7548-8782)
- Chinkuli Munkombwe
- Cadence Claar‐Pressley
Institutions
- Emory University (US)
- Georgia State University (US)
- Université Catholique du Congo (CD)
- Center for Translational Research in Neuroimaging and Data Science (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70768
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Emory University
- National Institutes of Health
- Goizueta Business School, Emory University
- National Institute on Aging