Inner and outer retinal abnormalities detected in Alzheimer's disease subjects diagnosed by amyloid PET not revealed when classified based on clinical criteria
Retinal studies in Alzheimer's disease yield mixed results when based on clinical criteria.Amyloid positron emission tomography classification permits recognition of retinal changes missed clinically.Optical coherence tomography (OCT) shows early macular thinning in amyloid beta positive subjects at the expense of inner layers.Electroretinography detects outer retinal dysfunction, indicating broader involvement.Retinal function loss on electroretinography precedes inner/outer changes on OCT.
Authors
- Daniele de Paula Faria (ORCID: https://orcid.org/0000-0002-1766-2786)
- Thais de Souza Andrade (ORCID: https://orcid.org/0000-0003-0518-1771)
- Juliana Emy Yokomizo (ORCID: https://orcid.org/0000-0002-3560-8193)
- Leonardo E. Ariello (ORCID: https://orcid.org/0000-0002-7031-2419)
- Fábio Henrique de Gobbi Porto (ORCID: https://orcid.org/0000-0002-3669-0950)
- Rim Nasser
- Geraldo F. Busatto (ORCID: https://orcid.org/0000-0003-4749-4602)
- Fábio Duran (ORCID: https://orcid.org/0000-0002-7603-6152)
- Mário Luiz Ribeiro Monteiro (ORCID: https://orcid.org/0000-0002-7281-2791)
- Carlos Alberto Buchpiguel (ORCID: https://orcid.org/0000-0003-0956-2790)
- Leonardo Provetti Cunha (ORCID: https://orcid.org/0000-0001-7984-1790)
- Maria Kiyoko Oyamada
- Georgia K. Westenhofen
Institutions
- Universidade Federal de Juiz de Fora (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70218
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidade de São Paulo