Widespread gray and white matter microstructural alterations in dual cognitive–motor deficit
Dual cognitive-motor deficit strongly predicts dementia in older adults.Five hundred eighty-two individuals were classified by cognitive and motor deficiency.Mean apparent propagator magnetic resonance imaging (MRI) and diffusion tensor imaging identified widespread microstructural brain alterations.Only the dual deficit showed significant gray matter and white matter differences after correction.Results support early detection of dementia via diffusion MRI microstructure metrics.
Authors
- Kavita Singh (ORCID: https://orcid.org/0000-0002-5400-757X)
- Kurt G. Schilling (ORCID: https://orcid.org/0000-0003-3686-7645)
- Dan Benjamini (ORCID: https://orcid.org/0000-0002-9558-7056)
- Yang An (ORCID: https://orcid.org/0000-0002-3312-7265)
Institutions
- Institute on Aging (US)
- National Institute on Aging (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/dad2.70204
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health